Evolutionary and comparative genomics of leptospira

Authors

  • Natalia Rego Institut Pasteur de Montevidéo, Unidad de Bioinformática, Montevidéo, Uruguai
  • Hugo Naya Institut Pasteur de Montevidéo, Unidad de Bioinformática, Montevidéo, Uruguai
  • Guillermo Lamolle Universidad de la República, Sección Biomatemática, Facultad de Ciencias, Montevideo, Uruguay
  • Fernando Álvarez-Valin Universidad de la República, Sección Biomatemática, Facultad de Ciencias, Montevideo, Uruguay

DOI:

https://doi.org/10.3395/reciis.v1i2.928

Keywords:

Leptospira, genome reduction, GC content, substitution rates, host range

Abstract

The availability of complete genome sequences has allowed the study of genic and nucleotide content changes during the evolution of pathogenic and symbiont bacterial lineages. Here we present the comparative genomics between four strains belonging to two species, Leptospira interrogans (L.interrogans Lai str. 56601 and L. interrogans Copenhageni str. Fiocruz L1-130) and L. borgpetersenii (L. borgpetersenii serovar Hardjo-bovis str. JB197 and L. borgpetersenii serovar Hardjo-bovis str. L550). Strains from the latter species have reduced their host range being restricted to a host-to-host transmission cycle while the former species could survive for long periods in fresh water. A detailed compositional and substitutional analysis of 2416 tetrads of orthologs indicates that this change in environmental condition is accompanied by changes in genomic GC content that affected the entire genome. Moreover, this analysis reveals that the interspecies divergence is surprisingly large, with a synonymous/amino acid distances ratio equal to 7.17, a ratio much larger than in other groups. We show that this increased ratio is an indication of acceleration in substitutions rates that especially affected synonymous positions and is in connection with the change in base composition already described. We hypothesize that this process specifically took place in the branch that leads to L. borgpetersenii.

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Published

2007-12-31

How to Cite

Rego, N., Naya, H., Lamolle, G., & Álvarez-Valin, F. (2007). Evolutionary and comparative genomics of leptospira. Revista Eletrônica De Comunicação, Informação & Inovação Em Saúde, 1(2). https://doi.org/10.3395/reciis.v1i2.928

Issue

Vol. 1 No. 2 (2007): Suplemento - Bioinformática e Saúde

Section

Original articles

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